Understanding of the effect of HIV treatment on HIV transmission risk has increased enormously over the last few years. The following studies show that successful HIV treatment suppresses the amount of HIV in a person’s blood, making HIV transmission very unlikely.
Reports an interim analysis of the relationship between undetectable viral load and HIV transmission in the Opposites Attract observational cohort study of homosexual male serodiscordant couples in Australia. Finds no linked HIV transmissions in 150 ‘couple years of follow up’ among homosexual male serodiscordant couples, despite close to six thousand acts of condomless anal sex.
Analyses 14 studies to find evidence about the effects of STI co-infection on transmission from individuals on ART is very limited. Available data suggests the average effect of STI co-infection on HIV viral load in individuals on ART is unlikely to decrease the effectiveness of treatment as prevention. However, limited data precluded ruling out the possibility that particular STIs pose a larger threat.
Meta-analysis suggests minimal risk of sexual HIV transmission for heterosexual serodiscordant couples when the HIV-positive partner has full viral suppression on cART with caveats regarding information on sexual intercourse type, STIs, and condom use.
Systemic review and meta-analysis of 50 studies considered HIV transmission risk between heterosexual partners. Found ART substantially reduces HIV infection risk within serodiscordant couples.
Reports findings of OPTN 052 study based in nine countries, which found early initiation of antiretroviral therapy reduced rates of sexual transmission of HIV-1 and clinical events, indicating both personal and public health benefits from such therapy.
Describes findings of the HPTN 052 study: that early initiation of antiretroviral therapy reduced rates of sexual transmission of HIV-1 and clinical events, indicating both personal and public health benefits from such therapy.
Review of existing studies to show that a person with HIV who has no other sexually transmissible infection, has adhered to antiretroviral therapy (ART) for at least 6 months to achieve completely suppressed viremia, and is monitored by an attending physician cannot pass on the virus through sexual contact.
Outlines the background to the Swiss Statement, reactions to the Swiss Statement, and the fact that subsequent research has not undermined its assertions. Includes observations about its legacy, including more honest communication between patients and clinicians, and the development of official guidelines recognising the effectiveness of ART.
Review and meta-analysis of 11 articles found no HIV transmission among heterosexual discordant couples when the positive patient was treated with ART and had a viral load below 400 copies (with data compatible with one transmission per 79 years).
Considers the reliability of viral load as a condition preventing HIV transmission. Found reliability is high with compliance taking medication the most important factor predicting reliability.
UNAIDS factsheet explaining how twenty years of evidence demonstrate that HIV treatment is highly effective in reducing the transmission of HIV. People living with HIV on antiretroviral therapy who have an undetectable level of HIV in their blood have a negligible risk of transmitting HIV sexually.
Twenty scientists from regions across the world developed this Expert Consensus Statement to address the use of HIV science by the criminal justice system. Description of the possibility of HIV transmission was limited to acts most often at issue in criminal cases. The authors recommend that caution be exercised when considering prosecution, and encourage governments and those working in legal and judicial systems to pay close attention to the significant advances in HIV science that have occurred over the last three decades to ensure current scientific knowledge informs application of the law in cases related to HIV.
Study findings provide conclusive evidence that the risk of HIV transmission through anal sex when HIV viral load is suppressed is effectively zero.Among the 782 serodifferent gay couples followed for almost 1600 eligible couple-years of follow-up, which included more than 76 000 reports of condomless sex, zero cases of within-couple HIV transmission were found. In the absence of ART, on the basis of the frequency and type of sex, for receptive condomless anal sex acts alone approximately 472 transmissions would have been expected. The results give equivalence of evidence for gay men as for heterosexual couples and indicate that the risk of HIV transmission when HIV viral load is suppressed is effectively zero for both anal and vaginal sex.
Overview of U=U, explaining how effective treatment lowers the level of HIV (the viral load) in the blood to a level where sexual transmission of HIV is no longer possible. When the levels are extremely low (below 200 copies/ml of blood measured) it is referred to as an undetectable viral load. At this stage, HIV cannot be passed on sexually.
Summary of a study published in June 2022 on the Taylor & Francis Online website. The qualitative study was conducted in August 2020 with extensive interviews via Zoom with twenty HIV-positive gay men on treatment with undetectable viral loads. Participants were from all regions of the United States and ranged in age from 23 to 62.
This article documents key moments in research and WHO policies that have informed how ART is applied within HIV programs, including as a prevention tool with the potential to support efforts to address HIV-related discrimination. In 2023, WHO continues to clarify that there is zero risk of sexual HIV transmission when a person living with HIV has an undetectable viral load and an almost zero or negligible risk of sexual transmission when a person living with HIV has a viral load of ≤1000 copies/mL.
This policy brief describes key HIV viral load thresholds and the available viral load testing approaches for monitoring how well antiretroviral therapy is working for people living with HIV.
Key messages include:
The risk of sexual transmission of HIV from individuals with low-level HIV viraemia receiving antiretroviral therapy (ART) has important public health implications, especially in resource-limited settings that use alternatives to plasma-based viral load testing. This Article summarises the evidence related to sexual transmission of HIV at varying HIV viral load levels to inform messaging for people living with HIV, their partners, their health-care providers, and the wider public.
